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CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity.

机译：CK2介导的拓扑异构酶I的过度磷酸化靶向丝氨酸506，增强拓扑异构酶I-DNa结合，并增加细胞喜树碱的敏感性。

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Keya Bandyopadhyay; Pingchuan Li; Ruth A Gjerset;
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1. Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. [J] . Das BB, Sen N, Roy A, Nucleic Acids Research . 2006,第4期

机译：选定的黄酮和喜树碱对多形利什曼原虫双亚基拓扑异构酶I-DNA裂解复合物的差异诱导作用：黄酮对耐喜树碱的拓扑异构酶I的活性。
2. Microscopic modes and free energies for topoisomerase I-DNA covalent complex binding with non-camptothecin inhibitors by molecular docking and dynamics simulations [J] . Ning-Ning Wei, Adel Hamza, Ce Hao Theoretical chemistry accounts . 2013,第8期

机译：拓扑异构酶I-DNA共价复合物与非喜树碱抑制剂结合的微观模式和自由能，通过分子对接和动力学模拟
3. Camptothecin: roles of the D and E rings in binding to the topoisomerase I-DNA covalent binary complex. [J] . Hecht SM Current medicinal chemistry. Anti-cancer agents . 2005,第4期

机译：喜树碱：D和E环在与拓扑异构酶I-DNA共价二元复合物结合中的作用。
4. Paclitaxel-Loaded Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhance Selective Binding to Target Cancer Cells and Increased Cytotoxicity [C] . Tao Wang, Avni Clerk, Valery A Petrenko, Annual meeting exposition of the Controlled Release Society . 2010

机译：载有紫杉醇的胶束用MCF-7细胞特异性噬菌体蛋白修饰：增强对靶癌细胞的选择性结合并增加细胞毒性
5. CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506 Enhances Topoisomerase I–DNA Binding and Increases Cellular Camptothecin Sensitivity [O] . Keya Bandyopadhyay, Pingchuan Li, Ruth A. Gjerset -1

机译：拓扑异构酶I的CK2介导的过度磷酸化丝氨酸瞄准506提高拓扑异构酶I-DNa结合和增强细胞喜树碱灵敏度
6. Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway [O] . Jui-Ling Hsu, Yunn-Fang Ho, Tsai-Kun Li, 2012

机译：罗勒林通过在PKCδ的途径中增加了拓扑异构酶I-DNA裂解复合物的形成和稳定性，在人类激素难治性前列腺癌中引起了Camptothecin诱导的细胞毒性

CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity.

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